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The innervation density from these boutons did not differ significantly between either the different neurochemical or the morphological subclasses of these cells. This suggests a nonselective innervation of lamina I projection neurons from a subpopulation of CGRP /SP afferents containing CART peptide. These results provide anatomical evidence for involvement of CART peptide in spinal pain transmission. Citing Literature.

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Almost all (97.9)) randomly selected calcitonin generelated peptide (CGRP ))immunoreactive terminals were substance P (SP))positive and CART was detected in approximately half (48.6)) of them. Most (81.4)) of the CGRP /SPergic boutons were galanin and approximately half (49.0)) amphetamine boston of these contained CART.

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